Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulation
Moreno-Sanchez PM; Oudin A; Kisakol B; Dussmann H; Klein E; Baus V; Rolin C; Seguin-Devaux C · 2025 · Preprint
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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The finding, in one line
“ABSTRACT Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME).”
Abstract (excerpt)
ABSTRACT Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME). To achieve more predictive preclinical insights,…
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Metadata source: Europe PMC · DOI 10.1101/2025.11.20.689484