Bi-specific T-cell engagers (BiTEs) in prostate cancer and strategies to enhance development: hope for a BiTE-r future
Harriet Lampe; Laura Tam; Aaron R. Hansen · 2024 · Frontiers in Pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Metastatic castrate resistant prostate cancer (mCRPC) continues to have poor survival rates due to limited treatment options. Bi-specific T cell engagers (BiTEs) are a promising class of novel immunotherapies with demonstrated success in haematological malignancies and melanoma. BiTEs developed for tumour associated antigens in prostate cancer have entered clinical testing. These trials have been hampered by high rates of treatment related adverse events, minimal or transient anti-tumour efficacy and generation of high titres of anti-drug antibodies. This paper aims to analyse the challenges f
Abstract by Harriet Lampe; Laura Tam; Aaron R. Hansen, Frontiers in Pharmacology (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fphar.2024.1399802