A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
Ted Wun; Denis Soulières; Andrew L. Frelinger; Lakshmanan Krishnamurti; Enrico M. Novelli; Abdullah Kutlar; Kenneth I. Ataga; Charles Knupp · 2013 · Journal of Hematology & Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study. METHODS: The primary endpoint, safety, was measured by hemorrhagic events requiring medical intervention. Patients were randomized to prasugrel 5 mg daily (n = 41) or placebo (n = 21) for 30 days. Platelet function by VerifyNow® P2Y12 and vasodilator-stimulated phosphoprotein as
Abstract by Ted Wun; Denis Soulières; Andrew L. Frelinger; Lakshmanan Krishnamurti; Enrico M. Novelli; Abdullah Kutlar; Kenneth I. Ataga; Charles Knupp, Journal of Hematology & Oncology (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1756-8722-6-17