Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis
Eleni Frangou; Panagiotis Garantziotis; Maria Grigoriou; Aggelos Banos; Dionysis Nikolopoulos; Antigone Pieta; Stavros Doumas; Antonis Fanouriakis · 2022 · Annals of the Rheumatic Diseases
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
OBJECTIVES: Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched in affected kidneys. METHODS: We used mRNA-sequencing in effector (spleen) and target (kidneys, brain) tissues from lupus and control mice at sequential time points, and in the blood from 367 individuals (261 systemic lupus erythematosus (SLE) patients and 106 healthy individuals). Comparative cross-tissue and cross-species analyses were performed. The human dataset was split into training and validation sets and machine learning was
Abstract by Eleni Frangou; Panagiotis Garantziotis; Maria Grigoriou; Aggelos Banos; Dionysis Nikolopoulos; Antigone Pieta; Stavros Doumas; Antonis Fanouriakis, Annals of the Rheumatic Diseases (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1136/annrheumdis-2021-222069