Negative / Null Result ReportOpen accessMedicine· cited by 46

Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum

Phitsinee Thipubon; Chairat Uthaipibull; Sumalee Kamchonwongpaisan; Wachiraporn Tipsuwan; Somdet Srichairatanakool · 2015 · Malaria Journal

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Iron is an essential micronutrient required by all living organisms including malaria parasites (Plasmodium spp.) for many biochemical reactions, especially growth and multiplication processes. Therefore, malaria parasite needs to take up the iron from outside or/and inside the parasitized red blood cells (PRBC). Iron chelators are widely used for the treatment of thalassaemia-related iron overload and also inhibit parasite growth at levels that are non-toxic to mammalian cells. METHODS: Inhibitory effect of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green

Abstract by Phitsinee Thipubon; Chairat Uthaipibull; Sumalee Kamchonwongpaisan; Wachiraporn Tipsuwan; Somdet Srichairatanakool, Malaria Journal (2015) — licensed CC BY 4.0.

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