The Role of Oxidative Stress in Parkinson's Disease
Vera Dias; Eunsung Junn; M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium
Abstract by Vera Dias; Eunsung Junn; M. Maral Mouradian, Journal of Parkinson’s Disease (2013) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3233/jpd-130230